GSDMD Rabbit Monoclonal Antibody

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Catalog Number:MABN87750
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse GSDMD
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,FC 1:200-1:500,IP 1:20-1:50
Molecular Weight:Calculated MW:53 kDa; Observed MW:53,31 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,FC 1:200-1:500,IP 1:20-1:50

Immunogen

Recombinant protein of mouse GSDMD

Target Background

Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]

Synonyms:DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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