Immunological Sciences

HACE1 Mouse Monoclonal Antibody

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Catalog Number:MABN86102
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This HACE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human HACE1.
Reactivity:Human, Mouse, Rat
Applications:WB 1:1000-1:2000
Molecular Weight:102.3kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:E3 ubiquitin-protein ligase HACE1, 6.3.2.-, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320

Applications

WB 1:1000-1:2000

Immunogen

This HACE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human HACE1.

Target Background

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Synonyms:E3 ubiquitin-protein ligase HACE1, 6.3.2.-, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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