HDAC4 Rabbit Monoclonal Antibody

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Catalog Number:MABN21270
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG,Kappa
Clone:Monoclonal
Reactivity:Human,Mouse,Rat,
Applications:WB 1:2000-1:10000,IHC 1:50-1:200,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200
Molecular Weight:CalcuLated MW:119kD;Observed MW:140kD
Purification:Protein A
Form:Liquid
Synonyms:HDAC4;KIAA0288;Histone deacetylase 4;HD4

Applications

WB 1:2000-1:10000,IHC 1:50-1:200,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200

Target Background

Cell localization:Cytoplasm, Nucleus.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],

Synonyms:HDAC4;KIAA0288;Histone deacetylase 4;HD4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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