HDAC6 (3B2) Mouse Monoclonal Antibody

No images available

Catalog Number:MABN03492
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG2a
Clone:Monoclonal
Immunogen:A synthetic peptide of human HDAC6
Reactivity:Human,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 131 kDa; Observed MW: 160 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human HDAC6

Target Background

Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Synonyms:HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

No documents available.