HGF Mouse Monoclonal Antibody

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Catalog Number:MABN86051
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This HGF antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from human HGF.
Reactivity:Human, Mouse, Rat
Applications:WB 1:200-1:1000
Molecular Weight:83.1kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain, HGF, HPTA

Applications

WB 1:200-1:1000

Immunogen

This HGF antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from human HGF.

Target Background

Hepatocyte growth factor regulates cell growth, cellmotility, and morphogenesis by activating a tyrosine kinasesignaling cascade after binding to the proto-oncogenic c-Metreceptor. Hepatocyte growth factor is secreted by mesenchymal cellsand acts as a multi-functional cytokine on cells of mainlyepithelial origin. Its ability to stimulate mitogenesis, cellmotility, and matrix invasion gives it a central role inangiogenesis, tumorogenesis, and tissue regeneration. It issecreted as a single inactive polypeptide and is cleaved by serineproteases into a 69-kDa alpha-chain and 34-kDa beta-chain. Adisulfide bond between the alpha and beta chains produces theactive, heterodimeric molecule. The protein belongs to theplasminogen subfamily of S1 peptidases but has no detectableprotease activity. Alternative splicing of this gene producesmultiple transcript variants encoding different isoforms. [providedby RefSeq].

Synonyms:Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain, HGF, HPTA

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide.

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