HIF Prolyl Hydroxylases Rabbit Monoclonal Antibody

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Catalog Number:MABN84748
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human HIF PH4
Reactivity:Human
Applications:WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100,IP 1:20-1:50
Molecular Weight:Calculated MW: 57 kDa ; Observed MW: 47 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;;HIF PH4

Applications

WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100,IP 1:20-1:50

Immunogen

A synthesized peptide derived from human HIF PH4

Target Background

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Synonyms:EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;;HIF PH4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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