Immunological Sciences

Histone H1.8 Rabbit Polyclonal Antibody

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Catalog Number:ABN00419
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Reactivity:Human
Applications:IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000
Purification:Affinity Chromatography
Form:Liquid
Synonyms:H1.8; H1oo; osH1

Applications

IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000

Target Background

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling .

Synonyms:H1.8; H1oo; osH1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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