Immunological Sciences

HLA-DRA Mouse Monoclonal Antibody

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Catalog Number:MABN81770
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2b
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli.
Reactivity:Human
Applications:WB 1:500-1:2000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:28.6kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:MLRW; HLA-DRA1

Applications

WB 1:500-1:2000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli.

Target Background

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Synonyms:MLRW; HLA-DRA1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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