HMG4 Rabbit Monoclonal Antibody

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Catalog Number:MABN02097
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human HMG4
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 23 kDa; Observed MW: 23 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:HMG4; HMG-4; HMG2A; HMG-2a

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human HMG4

Target Background

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .

Synonyms:HMG4; HMG-4; HMG2A; HMG-2a

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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