Homer1 Rabbit Monoclonal antibody
Western blot analysis of Homer1 in mouse brain lysates using Homer1 antibody.
| Catalog Number: | MABN02110 |
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Clone: | Monoclonal |
| Immunogen: | Recombinant protein of human Homer1 |
| Reactivity: | Mouse,Rat |
| Applications: | WB 1:500-1:1000,IP 1:20-1:50 |
| Molecular Weight: | 46 kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines .
Applications
WB 1:500-1:1000,IP 1:20-1:50
Immunogen
Recombinant protein of human Homer1
