Immunological Sciences

Hsp105 (1A1) Rabbit Monoclonal Antibody

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Catalog Number:MABN12238
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Hsp105
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:50-1:200,ICC/IF 1:100-1:200,IP 1:10-1:100
Molecular Weight:97kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Antigen NY-CO-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1;

Applications

WB 1:1000-1:5000,IHC 1:50-1:200,ICC/IF 1:100-1:200,IP 1:10-1:100

Immunogen

A synthetic peptide of human Hsp105

Target Background

HSP105 a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Synonyms:Antigen NY-CO-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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