Immunological Sciences

Integrin alpha 6 (19T9) Rabbit Monoclonal Antibody

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Catalog Number:MABN12651
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Integrin alpha 6
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500
Molecular Weight:127kDa
Purification:Affinity purification
Form:Liquid
Synonyms:ITGA6; CD49 antigen-like family member F; VLA-6; CD49f;

Applications

WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500

Immunogen

A synthetic peptide of human Integrin alpha 6

Target Background

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).

Synonyms:ITGA6; CD49 antigen-like family member F; VLA-6; CD49f;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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