Integrin aVb3

Mouse anti-Integrin alphaVbeta3. Inhibition of angiogenesis on the chick chorioallantoic membrane by anti-alphaVbeta3

Mouse anti-Integrin alphaVbeta3. Inhibition of angiogenesis on the chick chorioallantoic membrane by anti-alphaVbeta3

Catalog Number:MAB-10055
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Ms
Isotype:IgG1
Clone:LM609
Reactivity:Hu, Bv, Ch, Cat, Rb, Mk
Applications:Flow Cytometry: suggested dil. 1/50 – 1/100 . Use 10 l of to label 106 cells.Immunoprecipitation Immunofluorescence: Inhibits adhesion of cells to vitronectin coated surfaces at 1- 25 g/mL Immunohistochemistry : IHC(frozen Tissues) not effective for IHC(P). Optimal working dilutions must be determined by end user.
Purification:Purified
Form:Liquid

Applications

Flow Cytometry: suggested dil. 1/50 – 1/100 . Use 10 l of to label 106 cells.Immunoprecipitation Immunofluorescence: Inhibits adhesion of cells to vitronectin coated surfaces at 1- 25 g/mL Immunohistochemistry : IHC(frozen Tissues) not effective for IHC(P). Optimal working dilutions must be determined by end user.

Target Background

The involvement of integrins in vascular proliferation, adhesion, and wound repair have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an a and b subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual a and b subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. Due to its involvement in angiogenesis, the integrin V3 receptor is one of the most intensely studied of the integrin receptors. Monoclonal antibody MAB10055 is reactive with the vitronectin receptor V3 complex, an RGD-directed adhesion receptor.

Storage

Maintain at 2-8 ° C.

Buffer

Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide

Mouse anti-Integrin alphaVbeta3. Inhibition of angiogenesis on the chick chorioallantoic membrane by anti-alphaVbeta3

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