Immunological Sciences

Integrin beta 3 (3C12) Mouse Monoclonal Antibody

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Catalog Number:MABN03440
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG1
Clone:Monoclonal
Immunogen:Recombinant protein of human Integrin beta 3
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 87 kDa; Observed MW: 110 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

Applications

WB 1:500-1:1000

Immunogen

Recombinant protein of human Integrin beta 3

Target Background

Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).

Synonyms:ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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