Immunological Sciences

Integrin beta 3 Rabbit Polyclonal Antibody

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Catalog Number:ABN00418
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Recombinant protein of human Integrin beta 3
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000
Molecular Weight:Calculated MW: 87 kDa; Observed MW: 87 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000

Immunogen

Recombinant protein of human Integrin beta 3

Target Background

Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).

Synonyms:ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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