Immunological Sciences

Interferon alpha/beta Receptor 1 Rabbit Polyclonal Antibody

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Catalog Number:ABN00041
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:A synthetic peptide of human Interferon alpha/beta receptor 1
Reactivity:Human
Applications:WB 1:500-1:1000,FC 1:50-1:100,IP 1:20-1:50
Molecular Weight:Calculated MW: 64 kDa; Observed MW: 90,130 kDa
Purification:Affinity Chromatography
Form:Liquid
Synonyms:IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

Applications

WB 1:500-1:1000,FC 1:50-1:100,IP 1:20-1:50

Immunogen

A synthetic peptide of human Interferon alpha/beta receptor 1

Target Background

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

Synonyms:IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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