Interleukin-1 Beta

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Catalog Number:AB-84394
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Rb
Isotype:IgG
Clone:POLY
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 124-223 of human IL1β.
Reactivity:Hu, Ms, Rt
Applications:WB
Molecular Weight:17kDa/30kDa
Purification:Aff. Pur.
Form:Liquid
Synonyms:IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B

Applications

WB

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 124-223 of human IL1β.

Target Background

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Synonyms:IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B

Storage

Store at -20℃. Avoid freeze / thaw cycles.

Buffer

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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