Immunological Sciences

IQGAP1 (14X7) Rabbit Monoclonal Antibody

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Catalog Number:MABN12719
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human IQGAP1
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:100-1:500,ICC/IF 1:100-1:200,FC 1:20-1:50
Molecular Weight:189kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Iqgap1; p195; SAR1;

Applications

WB 1:500-1:2000,IHC 1:100-1:500,ICC/IF 1:100-1:200,FC 1:20-1:50

Immunogen

A synthetic peptide of human IQGAP1

Target Background

Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).

Synonyms:Iqgap1; p195; SAR1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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