Immunological Sciences

IRF-9 (3N8) Rabbit Monoclonal Antibody

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Catalog Number:MABN12750
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Interferon regulatory factor 9
Reactivity:Human
Applications:WB 1:2000-1:20000,ICC/IF 1:100-1:200,FC 1:20-1:100
Molecular Weight:44kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Irf9; ISGF3; ISGF3G; p48;

Applications

WB 1:2000-1:20000,ICC/IF 1:100-1:200,FC 1:20-1:100

Immunogen

A synthetic peptide of human Interferon regulatory factor 9

Target Background

Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. Transcription factor that plays an essential role in anti- viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Synonyms:Irf9; ISGF3; ISGF3G; p48;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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