Immunological Sciences

IRF2 (19Z15) Rabbit Monoclonal Antibody

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Catalog Number:MABN12738
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human IRF2
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,IHC 1:50-1:100,ICC/IF 1:200-1:500
Molecular Weight:39kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Interferon regulatory factor 2; IRF 2;

Applications

WB 1:500-1:2000,IHC 1:50-1:100,ICC/IF 1:200-1:500

Immunogen

A synthetic peptide of human IRF2

Target Background

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. IRF-2 acts as both a transcription activator and repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Synonyms:Interferon regulatory factor 2; IRF 2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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