Immunological Sciences

IRF8 Rabbit Monoclonal Antibody

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Catalog Number:MABN85716
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human IRF8
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,IP 1:10-1:20
Molecular Weight:Calculated MW: 48 kDa; Observed MW: 48 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP

Applications

WB 1:500-1:1000,IHC 1:50-1:100,IP 1:10-1:20

Immunogen

Recombinant protein of human IRF8

Target Background

Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .

Synonyms:ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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