Immunological Sciences

ITGAM Mouse Monoclonal Antibody

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Catalog Number:MABN81276
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.
Reactivity:Human
Applications:ICC 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:127.1kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

Applications

ICC 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.

Target Background

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms:CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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