Immunological Sciences

JAB1 Rabbit Monoclonal Antibody

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Catalog Number:MABN87273
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human JAB1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:38 kDa; Observed MW:38 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CSN5; JAB1; SGN5; MOV-34

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human JAB1

Target Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Synonyms:CSN5; JAB1; SGN5; MOV-34

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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