Immunological Sciences

JAK2 Mouse Monoclonal Antibody

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Catalog Number:MABN84993
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Synthetic peptide conjugated to KLH.
Reactivity:Human,Mouse,Rat
Applications:IHC 1:50-1:100
Purification:Affinity Purification
Form:Liquid
Synonyms:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Applications

IHC 1:50-1:100

Immunogen

Synthetic peptide conjugated to KLH.

Target Background

Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Synonyms:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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