JAK2 Rabbit Monoclonal antibody

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Catalog Number:MABN03780
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide corresponding to target protein
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 131 kDa; Observed MW: 131 kDa
Purification:Affinity Purified
Form:Liquid
Synonyms:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide corresponding to target protein

Target Background

Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Synonyms:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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