JNK1 (1A4) Mouse Monoclonal Antibody
Western blot analysis of JNK1 in C6 and 3T3 lysates using JNK1 antibody.
| Catalog Number: | MABN03520 |
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | IgG2a |
| Clone: | 1A4 |
| Immunogen: | A synthetic peptide corresponding to target protein. |
| Reactivity: | Human,Mouse,Rat |
| Applications: | Western Blot: 1:500-1:1000 Immunocytochemistry: 1:50-1:200 Immunofluorescence: 1:50-1:200 |
| Molecular Weight: | 48 kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | c Jun N terminal kinase 1; C-JUN kinase 1 |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Applications
Western Blot: 1:500-1:1000 Immunocytochemistry: 1:50-1:200 Immunofluorescence: 1:50-1:200
Immunogen
A synthetic peptide corresponding to target protein.
