KCTD21 Rabbit Monoclonal Antibody

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Catalog Number:MABN85729
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human KCTD21
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 30 kDa; Observed MW: 30 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:KCASH2

Applications

WB 1:500-1:1000

Immunogen

Recombinant protein of human KCTD21

Target Background

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Synonyms:KCASH2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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