KMT6 Rabbit Monoclonal Antibody

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Catalog Number:MABN85738
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human KMT6/EZH2
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,ICC 1:50-1:200
Molecular Weight:Calculated MW: 85 kDa; Observed MW: 98 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2

Applications

WB 1:500-1:1000,ICC 1:50-1:200

Immunogen

A synthetic peptide of human KMT6/EZH2

Target Background

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Synonyms:WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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