[KO Validated] CDK5 Rabbit mAb

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Applications

WB,1:1000 - 1:5000

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 92-289 of human CDK5. (NP_004926.1).

Storage

Store at -20℃. Avoid freeze / thaw cycles.