KU80

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Catalog Number:AB-11718
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Rb
Isotype:IgG
Clone:POLY
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 543-732 of human KU86
Reactivity:Hu, Ms, Rt
Applications:Western Blot: 1:500 -1:2000 Immunohistochemistry: 1:100 -1:200 Immunofluorescence: 1:20 -1:100 Immunoprecipitation: 1:50 - 1:200
Molecular Weight:86kDa
Purification:Purified
Form:Liquid
Synonyms:KU86; KARP-1; KARP1; KU80; KUB2; Ku86; NFIV;X-ray repair cross complementing 5

Applications

Western Blot: 1:500 -1:2000 Immunohistochemistry: 1:100 -1:200 Immunofluorescence: 1:20 -1:100 Immunoprecipitation: 1:50 - 1:200

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 543-732 of human KU86

Target Background

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein KU86. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA doublestrand break by non-homologous end joining and the completion of V(D)Jrecombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Synonyms:KU86; KARP-1; KARP1; KU80; KUB2; Ku86; NFIV;X-ray repair cross complementing 5

Storage

Store at -20℃. Avoid freeze / thaw cycles

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

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