Immunological Sciences

Ku80 Rabbit Monoclonal Antibody

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Catalog Number:MABN87254
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Ku80
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:200-1:500,FC 1:50-1:200
Molecular Weight:Calculated MW:83 kDa; Observed MW:83 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:KU80; KUB2; Ku86; NFIV; KARP1; KARP-1

Applications

WB 1:500-1:2000,IHC 1:200-1:500,FC 1:50-1:200

Immunogen

A synthetic peptide of human Ku80

Target Background

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Synonyms:KU80; KUB2; Ku86; NFIV; KARP1; KARP-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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