Immunological Sciences

Lamin A/C Mouse Monoclonal Antibody

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Catalog Number:MABN03873
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG2a
Clone:Monoclonal
Immunogen:A synthetic peptide of human Lamin A/C
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 74 kDa; Observed MW: 74 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:LMNA; LMN1; Prelamin-A/C

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human Lamin A/C

Target Background

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Synonyms:LMNA; LMN1; Prelamin-A/C

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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