Immunological Sciences

LASP-1 Rabbit Polyclonal Antibody

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Catalog Number:ABN13220
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:50-1:300
Molecular Weight:28kDa
Purification:Affinity purification
Form:Liquid
Synonyms:LASP1; MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50

Applications

WB 1:500-1:2000,IHC 1:50-1:300

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100

Target Background

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin.,

Synonyms:LASP1; MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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