Immunological Sciences

LAT Rabbit Polyclonal Antibody

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Catalog Number:ABN03358
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Synthesized peptide derived from LAT . at AA range: 190-270
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,ELISA 1:5000-1:20000
Molecular Weight:Calculated MW: 28 kDa; Observed MW: 28 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

Applications

WB 1:500-1:1000,ELISA 1:5000-1:20000

Immunogen

Synthesized peptide derived from LAT . at AA range: 190-270

Target Background

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Synonyms:LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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