Immunological Sciences

LRP1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86486
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human LRP1
Reactivity:Human,Mouse,Rat
Applications:WB 1:2000-1:20000,IHC 1:50-1:100,ICC/IF 1:100-1:200,FC 1:50-1:200,IP 1:20-1:50
Molecular Weight:Calculated MW:85 kDa; Observed MW:85 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R

Applications

WB 1:2000-1:20000,IHC 1:50-1:100,ICC/IF 1:100-1:200,FC 1:50-1:200,IP 1:20-1:50

Immunogen

A synthetic peptide of human LRP1

Target Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Synonyms:APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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