LXR alpha Rabbit Monoclonal Antibody

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Catalog Number:MABN83944
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human NR1H3
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000,ICC 1:50-1:200,FC 1:20-1:100
Molecular Weight:50 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Liver X receptor alpha; LXR a; LXRA; NR1H3; RLD1;;NR1H3

Applications

WB 1:1000-1:2000,ICC 1:50-1:200,FC 1:20-1:100

Immunogen

A synthesized peptide derived from human NR1H3

Target Background

Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Synonyms:Liver X receptor alpha; LXR a; LXRA; NR1H3; RLD1;;NR1H3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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