Immunological Sciences

MAP3K7 Mouse Monoclonal Antibody

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Catalog Number:MABN81452
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2a
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.
Reactivity:Human
Applications:ELISA 1:5000-1:20000
Molecular Weight:67.2kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TAK1; MEKK7; TGF1a

Applications

ELISA 1:5000-1:20000

Immunogen

Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.

Target Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms:TAK1; MEKK7; TGF1a

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.

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