MARK3 (4Z8) Rabbit Monoclonal Antibody

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Catalog Number:MABN13650
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Mark3
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,ICC/IF 1:50-1:100,FC 1:50-1:100,IP 1:20-1:100
Molecular Weight:84kDa
Purification:Affinity purification
Form:Liquid
Synonyms:C-TAK1; cTAK1; Emk2; KP78; Mark3; PAR1A;

Applications

WB 1:500-1:2000,ICC/IF 1:50-1:100,FC 1:50-1:100,IP 1:20-1:100

Immunogen

A synthetic peptide of human Mark3

Target Background

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

Synonyms:C-TAK1; cTAK1; Emk2; KP78; Mark3; PAR1A;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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