MBNL1 Rabbit Monoclonal Antibody

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Catalog Number:MABN84338
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human MBNL1
Reactivity:Human,Mouse
Applications:WB 1:1000-1:2000
Molecular Weight:Calculated MW: 42 kDa ; Observed MW: 40 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:EXP; EXP35; EXP40; EXP42; MBNL; MBNL1;;MBNL1

Applications

WB 1:1000-1:2000

Immunogen

A synthesized peptide derived from human MBNL1

Target Background

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA.

Synonyms:EXP; EXP35; EXP40; EXP42; MBNL; MBNL1;;MBNL1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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