Immunological Sciences

MCM3 Mouse Monoclonal Antibody

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Catalog Number:MABN82938
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human MCM3 expressed in E. Coli.
Reactivity:Human,Rat,Monkey
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,ICC 1:50-1:200,FC 1:200-1:400
Molecular Weight:91kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:HCC5; P1.h; RLFB; P1-MCM3

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,ICC 1:50-1:200,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human MCM3 expressed in E. Coli.

Target Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms:HCC5; P1.h; RLFB; P1-MCM3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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