Immunological Sciences

MDM2 Mouse Monoclonal Antibody

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Catalog Number:MABN81436
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2a
Clone:Monoclonal
Immunogen:Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc).
Reactivity:Human
Applications:ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:55.2kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DMX; hdm2; ACTFS

Applications

ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc).

Target Background

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Synonyms:DMX; hdm2; ACTFS

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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