Immunological Sciences

mGluR5 Rabbit Polyclonal Antibody

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Catalog Number:ABN13862
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:130kDa
Purification:Affinity purification
Form:Liquid
Synonyms:GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5

Applications

WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70

Target Background

glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,

Synonyms:GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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