Immunological Sciences

MIF Rabbit Polyclonal Antibody

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Catalog Number:ABN13901
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human MIF. AA range:25-74
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:50-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000
Molecular Weight:12kDa
Purification:Affinity purification
Form:Liquid
Synonyms:MIF; GLIF; MMIF; Macrophage migration inhibitory factor; MIF; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase

Applications

WB 1:500-1:2000,IHC 1:50-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human MIF. AA range:25-74

Target Background

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008],catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate.,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,similarity:Belongs to the MIF family.,subunit:Homotrimer. Interacts with COPS5 and BNIPL.,

Synonyms:MIF; GLIF; MMIF; Macrophage migration inhibitory factor; MIF; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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