Immunological Sciences

MITF Mouse Monoclonal Antibody

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Catalog Number:MABN86015
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF.
Reactivity:Human, Mouse, Rat
Applications:WB 1:1000-1:2000,IHC 1:500-1:2000
Molecular Weight:58.8kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32

Applications

WB 1:1000-1:2000,IHC 1:500-1:2000

Immunogen

This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF.

Target Background

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Synonyms:Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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