MLK1 Rabbit Polyclonal Antibody

Target Background

MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 includeretroperitoneal neuroblastoma. Among its related pathways areMAP Kinase SignalingandTGF-Beta Pathway. GO annotations related to this gene includeprotein homodimerization activityandprotein kinase activity. An important paralog of this gene isKSR1. catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,