Immunological Sciences

MRC2/ENDO180 (10A4) Rabbit Monoclonal Antibody

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Catalog Number:MABN14079
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human MRC2
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:167kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CD280 antigen; MRC2; ENDO180; KIAA0709; UPARAP;

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human MRC2

Target Background

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Synonyms:CD280 antigen; MRC2; ENDO180; KIAA0709; UPARAP;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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