Immunological Sciences

MUM1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86500
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human MUM1
Reactivity:Human
Applications:WB 1:2000-1:20000,IHC 1:200-1:500,ICC/IF 1:200-1:500,FC 1:100-1:1000,IP 1:100-1:500
Molecular Weight:Calculated MW:52 kDa; Observed MW:52 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:MUM1; LSIRF; SHEP8; NF-EM5

Applications

WB 1:2000-1:20000,IHC 1:200-1:500,ICC/IF 1:200-1:500,FC 1:100-1:1000,IP 1:100-1:500

Immunogen

A synthetic peptide of human MUM1

Target Background

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Synonyms:MUM1; LSIRF; SHEP8; NF-EM5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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