Munc 13-4 Rabbit Monoclonal Antibody

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Catalog Number:MABN03987
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Munc 13-4
Reactivity:Human, Mouse
Applications:WB 1:500-1:1000,FC 1:50-1:100
Molecular Weight:Calculated MW:123 kDa;Observed MW: 123 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Munc13-4,Protein unc-13 homolog D

Applications

WB 1:500-1:1000,FC 1:50-1:100

Immunogen

A synthetic peptide of human Munc 13-4

Target Background

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.

Synonyms:Munc13-4,Protein unc-13 homolog D

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

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