Immunological Sciences

MYC Mouse Monoclonal Antibody

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Catalog Number:MABN82414
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2b
Clone:Monoclonal
Immunogen:Synthesized peptide of human MYC (AA: 23-37)
Reactivity:Human
Applications:ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:48.8kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:MRTL; MYCC; c-Myc; bHLHe39

Applications

ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Synthesized peptide of human MYC (AA: 23-37)

Target Background

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Synonyms:MRTL; MYCC; c-Myc; bHLHe39

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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