Immunological Sciences

MYSM1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86632
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human MYSM1
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IP 1:50-1:200
Molecular Weight:Calculated MW:95 kDa; Observed MW:96,55 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:2ADUB; 2A-DUB

Applications

WB 1:500-1:2000,IP 1:50-1:200

Immunogen

Recombinant protein of human MYSM1

Target Background

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Synonyms:2ADUB; 2A-DUB

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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